DIVERSE
PD
DIVERSE
PD
The DIVERSE-PD study
DIVERSE-PD is a UK research study based at University College London (UCL), aiming to improve our understanding of the genetic causes of Parkinson’s disease.
Although research has identified several genes associated with Parkinson’s, the underlying causes remain unknown for many people. By investigating the genetic factors that contribute to Parkinson’s, we hope to uncover new insights into how the condition develops and identify new avenues for future research.
We are particularly interested in people who developed Parkinson’s symptoms at a younger age, those with a family history of the condition, and people from under-represented ethnic backgrounds. These groups may provide valuable insights into the genetic factors involved in Parkinson’s, yet some remain under-represented in genetic research.
Through the collection of clinical information, family history and genetic data, DIVERSE-PD aims to identify genetic changes associated with Parkinson’s and improve our understanding of the biological processes underlying the condition. By bringing together people with a diverse range of backgrounds and experiences, we hope to build a more representative understanding of Parkinson’s genetics and contribute to discoveries that will inform future research into the condition and its treatment.
Why Genetics Matters in Parkinson’s Disease
Parkinson's and Genetics
Up to 85% of people living with Parkinson's disease do not have a known genetic cause
Parkinson’s disease is a complex condition influenced by a combination of genetic, environmental and other factors. Our genes contain the instructions that help our bodies function, and changes in certain genes can affect how cells work and increase the risk of developing Parkinson’s disease.
Research has identified multiple genes linked to Parkinson’s. Approximately 15% of people over the age of 50 living with the condition having a known genetic cause. In others, genetic variations may contribute to an increased risk without being the sole cause. Genetics appears to play a particularly important role in some people who develop Parkinson’s at a younger age or have a family history of the condition.
Despite advances in research, approximately 85% of people will receive a diagnosis of idiopathic Parkison’s disease, meaning that no clear cause has been found. By working with people from different backgrounds, family histories and experiences of Parkinson’s, we intend to identify undiscovered genetic changes associated with the condition and better understand how they contribute to its development.
In the longer term, this knowledge could help improve genetic diagnosis, inform genetic counselling for people with Parkinson’s and their families, and identify new avenues for research into potential treatments.